An endophenotype is a heritable trait that is generally considered to be more highly,
associated with a gene-based neurological deficit than a disease phenotype itself. Such …

Phosphodiesterase 11A (PDE11A) is the most recently discovered 3', 5'-cyclic nucleotide
phosphodiesterase. By breaking down both cAMP and cGMP, PDE11A is a critical regulator …

Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders,
and in many disease states, dopamine receptor number is altered. Here we identify a …

The aim of the present study was to test a possible effect of the G-protein β3-subunit (Gβ3)
C825T gene variant on the antidepressant activity of selective serotonin reuptake inhibitors …

Despite the fact that appropriate social behaviors are vital to thriving in one's environment,
little is understood of the molecular mechanisms controlling social behaviors or how social …

Schizophrenia is a widespread psychiatric disorder, affecting 1% of people. Despite this
high prevalence, schizophrenia is not well treated because of its enigmatic developmental …

Sensorimotor gating, the ability to automatically filter sensory information, is deficient in a
number of psychiatric disorders, yet little is known of the biochemical mechanisms …

Abstract The most recently discovered 3′, 5′-cyclic nucleotide phosphodiesterase family
is the Phosphodiesterase 11 (PDE11) family, which is encoded by a single gene PDE11A …

We studied the possible association between the prophylactic efficacy of lithium in mood
disorders and the following gene variants: catechol‐O‐methyltransferase (COMT) G158A …

One of the major challenges in the field of neurobiology is to elucidate the molecular
machinery that underlies the formation and storage of memories. For many decades, genetic …