Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …

The neural crest is a migratory population of embryonic cells with a tremendous potential to
differentiate and contribute to nearly every organ system in the adult body. Over the past two …

Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Ovarian cancer (OC) can be classified into five biologically distinct molecular subgroups:
epithelial-A (Epi-A), Epi-B, mesenchymal (Mes), Stem-A and Stem-B. Among them, Stem-A …

The neural crest is a fascinating embryonic population unique to vertebrates that is endowed
with remarkable differentiation capacity. Thought to originate from ectodermal tissue, neural …

Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a
diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells …

Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate
Wnt receptors. Frizzled7 is highly conserved through evolution, from Hydra through to …

MicroRNAs (miRNAs) are a class of small noncoding RNAs that play important roles in
tumorigenesis and tumor progression through regulation of gene expression. Earlier, miR …