The hepatitis delta virus: Replication and pathogenesis

C Sureau, F Negro - Journal of hepatology, 2016 - Elsevier
Hepatitis delta virus (HDV) is a defective virus and a satellite of the hepatitis B virus (HBV).
Its RNA genome is unique among animal viruses, but it shares common features with some …

Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis delta

D Roulot, S Brichler, R Layese, Z BenAbdesselam… - Journal of …, 2020 - Elsevier
Background & Aims HDV infection causes severe chronic liver disease in individuals
infected with HBV. However, the factors associated with poor prognosis are largely …

Hepatitis delta virus: From biological and medical aspects to current and investigational therapeutic options

D Alfaiate, P Dény, D Durantel - Antiviral research, 2015 - Elsevier
An estimated 15–20 million individuals are co-infected by hepatitis B and hepatitis D virus
worldwide and are at high risk of developing end-stage liver disease, including …

Peginterferon alfa-2a plus tenofovir disoproxil fumarate for hepatitis D (HIDIT-II): a randomised, placebo controlled, phase 2 trial

H Wedemeyer, C Yurdaydin, S Hardtke… - The Lancet infectious …, 2019 - thelancet.com
Background Hepatitis D is the most severe form of chronic viral hepatitis. Treatment
guidelines recommend 1 year of peginterferon alfa, which is effective in 25–30% of patients …

[PDF][PDF] Antiviral treatment and liver‐related complications in hepatitis delta

A Wranke, BC Serrano, B Heidrich, J Kirschner… - …, 2017 - Wiley Online Library
Hepatitis delta virus (HDV) is the most severe form of viral hepatitis. Pegylated interferon alfa
(PEG‐IFNα) is effective in only 25%‐30% of patients and is associated with frequent side …

Clinical and virological heterogeneity of hepatitis delta in different regions world‐wide: the Hepatitis Delta International Network (HDIN)

A Wranke, LM Pinheiro Borzacov, R Parana… - Liver …, 2018 - Wiley Online Library
Abstract Background & Aims Chronic hepatitis D (delta) is a major global health burden.
Clinical and virological characteristics of patients with hepatitis D virus (HDV) infection and …

Hepatitis B and Hepatitis D Viruses: A Comprehensive update with an immunological focus

DG Sausen, O Shechter, W Bietsch, Z Shi… - International Journal of …, 2022 - mdpi.com
Hepatitis B virus (HBV) and hepatitis delta virus (HDV) are highly prevalent viruses
estimated to infect approximately 300 million people and 12–72 million people worldwide …

Hepatitis D infection: from initial discovery to current investigational therapies

BL Da, T Heller, C Koh - Gastroenterology Report, 2019 - academic.oup.com
Hepatitis D is the most severe form of viral hepatitis associated with a more rapid
progression to cirrhosis and an increased risk of hepatocellular carcinoma and mortality …

Noninvasive markers for staging fibrosis in chronic delta hepatitis

V Takyar, P Surana, DE Kleiner… - Alimentary …, 2017 - Wiley Online Library
Background Serum fibrosis markers are useful in staging chronic hepatitis B (HBV) and C
(HCV) virus but have not been evaluated in chronic hepatitis D virus (HDV). Aim To evaluate …

Clinical long-term outcome of hepatitis D compared to hepatitis B monoinfection

A Wranke, B Heidrich, K Deterding… - Hepatology …, 2023 - Springer
Background and aims Hepatitis D virus (HDV) infection causes the most severe form of
chronic viral hepatitis. However, it is still unclear to what extent the underlying cirrhosis may …