Recent advances in the synthesis of nitrogen-containing heterocyclic compounds via multicomponent reaction and their emerging biological applications: a review
Mallappa, M Chahar, N Choudhary, KK Yadav… - Journal of the Iranian …, 2024 - Springer
Nitrogen-containing heterocyclic compounds (NCHCs) have an important role in the field of
medicinal chemistry due to their extensive biological activities and their prevalence in …
medicinal chemistry due to their extensive biological activities and their prevalence in …
Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity
A Sabt, MH Abdulla, MS Ebaid, J Pawełczyk… - Frontiers in …, 2024 - frontiersin.org
The spread of drug-resistant tuberculosis strains has become a significant economic burden
globally. To tackle this challenge, there is a need to develop new drugs that target specific …
globally. To tackle this challenge, there is a need to develop new drugs that target specific …
Discovery of new quinoline derivatives bearing 1-aryl-1, 2, 3-triazole motif as influenza H1N1 virus neuraminidase inhibitors
Sporadically and periodically, influenza outbreaks threaten global health and the economy.
Antigen drift-induced influenza virus mutations hamper antiviral drug development. Thus, a …
Antigen drift-induced influenza virus mutations hamper antiviral drug development. Thus, a …
Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier …
RZ Batran, A Sabt, J Dziadek, AF Kassem - RSC advances, 2024 - pubs.rsc.org
In this study, we designed and synthesized a series of coumarin derivatives as
antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme …
antitubercular agents targeting the enoyl acyl carrier protein reductase (InhA) enzyme …
Isoniazid Hybrids As Potential Antitubercular Agents
The rapid emergence of various forms of drug‐resistant tuberculosis (TB) has massively
impacted people's health globally. According to the WHO, TB care and facilities have been …
impacted people's health globally. According to the WHO, TB care and facilities have been …
Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with …
T Al-Warhi, A Sabt, M Korycka-Machala, AF Kassem… - RSC …, 2024 - pubs.rsc.org
Because resistant variants of the disease are always emerging, tuberculosis is a global
issue that affects economies. New antitubercular medications should be developed, and this …
issue that affects economies. New antitubercular medications should be developed, and this …
New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular …
AF Kassem, A Sabt, M Korycka-Machala… - Bioorganic …, 2024 - Elsevier
Tuberculosis is a global serious problem that imposes major health, economic and social
challenges worldwide. The search for new antitubercular drugs is extremely important which …
challenges worldwide. The search for new antitubercular drugs is extremely important which …
[HTML][HTML] Synthesis and Structure–Activity Relationship (SAR) Studies on New 4-Aminoquinoline-Hydrazones and Isatin Hybrids as Promising Antibacterial Agents
In response to the escalating crisis of antimicrobial resistance (AMR), there is an urgent
need to research and develop novel antibiotics. This study presents the synthesis and …
need to research and develop novel antibiotics. This study presents the synthesis and …