Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

The heartworm Dirofilaria immitis is an important parasite of dogs. Transmitted by
mosquitoes in warmer climatic zones, it is spreading across southern Europe and the …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

UDP-Galactopyranose mutase (UGM) is a flavin-containing enzyme that catalyzes the
reversible conversion of UDP-galactopyranose (UDP-Gal p) to UDP-galactofuranose (UDP …

Recently, the emergence and spread of pathogenic bacterial resistance to many antibiotics
(multidrug-resistant strains) have been increasing throughout the world. This phenomenon …

Although leishmaniasis has been studied for over a century, the fight against cutaneous,
mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to …

While target-based drug design has proved successful in several therapeutic areas, this
approach has not yet provided compelling outcomes in the field of antibacterial agents. This …

This study reports a novel class of inhibitors of uridine 5′‐diphosphate (UDP)
galactopyranose mutase (UGM) derived from a screening of natural products. This enzyme …

Galactofuranose (Gal f) is present in glycans critical for the virulence and viability of several
pathogenic microbes, including Mycobacterium tuberculosis, yet the monosaccharide is …