TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …

Liquid–liquid phase separation (LLPS) is involved in the formation of membraneless
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …

Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-
43) is associated with several neurodegenerative disorders, including ALS, frontotemporal …

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

The TAR DNA-binding protein of 43 kDa (TDP-43) has been identified as the main
component of amyotrophic lateral sclerosis (ALS) cytoplasmic inclusions. The link between …

Aberrant aggregation and amyloid formation of tar DNA binding protein (TDP-43) and α-
synuclein (αS) underlie frontotemporal dementia (FTD) and Parkinson's disease (PD) …

In patients with amyotrophic lateral sclerosis (ALS), disease symptoms and pathology
typically spread in a predictable spatiotemporal pattern beginning at a focal site of onset and …

Transactive response DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein
involved in transcriptional regulation and RNA processing. It is linked to sporadic and …

Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective
elimination of dysfunctional mitochondria. To this date, parkin depletion has been …