The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

Based on growing evidence linking autophagy to preconditioning, we tested the hypothesis
that autophagy is necessary for cardioprotection conferred by ischemic preconditioning …

Extracellular nucleotides, such as ATP and UTP, have distinct signaling roles through a
class of G-protein-coupled receptors, termed P2Y. The receptor ligands are typically …

We have previously shown that preischemic treatment with glucosamine improved cardiac
functional recovery following ischemia-reperfusion, and this was mediated, at least in part …

Uracil nucleotides (ie, UTP and UDP) have been known for years as fundamental
intermediates in the de novo synthesis of the other pyrimidine nucleotides, which altogether …

Purinergic signaling, mediated mainly by G protein-coupled P2Y receptors (P2YRs), is now
attracting attention as a new therapeutic target for preventing or treating cardiovascular …

Myocardial ischemia is the most common cardiovascular disease. Reperfusion, an important
myocardial ischemia tool, causes unexpected and irreversible damage to cardiomyocytes …

Представлены данные литературы по вопросам изучения фармакологической
активности различных представителей пиримидиновых производных. Принимая во …

Mitochondria play a pivotal role in intracellular Ca2+ signalling by taking up and releasing
the ion upon specific conditions. In order to do so, mitochondria depend on a number of …