Insights from genomes into the evolutionary importance and prevalence of hybridization in nature
Hybridization is an evolutionary phenomenon that has fascinated biologists for centuries.
Prior to the advent of whole-genome sequencing, it was clear that hybridization had played …
Prior to the advent of whole-genome sequencing, it was clear that hybridization had played …
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Accurate proteome-wide missense variant effect prediction with AlphaMissense
The vast majority of missense variants observed in the human genome are of unknown
clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on …
clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on …
Epigenetic patterns in a complete human genome
The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has
resolved complex regions of the genome, including repetitive and homologous regions …
resolved complex regions of the genome, including repetitive and homologous regions …
A global catalog of whole-genome diversity from 233 primate species
The rich diversity of morphology and behavior displayed across primate species provides an
informative context in which to study the impact of genomic diversity on fundamental …
informative context in which to study the impact of genomic diversity on fundamental …
fastsimcoal2: demographic inference under complex evolutionary scenarios
Motivation fastsimcoal2 extends fastsimcoal, a continuous time coalescent-based genetic
simulation program, by enabling the estimation of demographic parameters under very …
simulation program, by enabling the estimation of demographic parameters under very …
The landscape of tolerated genetic variation in humans and primates
H Gao, T Hamp, J Ede, JG Schraiber, J McRae… - Science, 2023 - science.org
Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …
individuals, but our understanding of their clinical relevance remains largely incomplete. To …
The genome of the offspring of a Neanderthal mother and a Denisovan father
Neanderthals and Denisovans are extinct groups of hominins that separated from each
other more than 390,000 years ago,. Here we present the genome of 'Denisova 11', a bone …
other more than 390,000 years ago,. Here we present the genome of 'Denisova 11', a bone …
Genomic insights into population history and biological adaptation in Oceania
J Choin, J Mendoza-Revilla, LR Arauna… - Nature, 2021 - nature.com
The Pacific region is of major importance for addressing questions regarding human
dispersals, interactions with archaic hominins and natural selection processes. However, the …
dispersals, interactions with archaic hominins and natural selection processes. However, the …
Conservation of biodiversity in the genomics era
MA Supple, B Shapiro - Genome biology, 2018 - Springer
Abstract “Conservation genomics” encompasses the idea that genome-scale data will
improve the capacity of resource managers to protect species. Although genetic approaches …
improve the capacity of resource managers to protect species. Although genetic approaches …