Understanding the mysterious M2 macrophage through activation markers and effector mechanisms

T Rőszer - Mediators of inflammation, 2015 - Wiley Online Library
The alternatively activated or M2 macrophages are immune cells with high phenotypic
heterogeneity and are governing functions at the interface of immunity, tissue homeostasis …

Neuropeptide Y is an immunomodulatory factor: direct and indirect

W Chen, Y Liu, W Liu, Y Zhou, H He, S Lin - Frontiers in immunology, 2020 - frontiersin.org
Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in
regulating a variety of biological processes, including food intake, energy metabolism, and …

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

A Perino, TWH Pols, M Nomura, S Stein… - The Journal of …, 2014 - Am Soc Clin Investig
The bile acid–responsive G protein–coupled receptor TGR5 is involved in several metabolic
processes, and recent studies suggest that TGR5 activation may promote pathways that are …

A promising therapeutic target for metabolic diseases: neuropeptide Y receptors in humans

M Yi, H Li, Z Wu, J Yan, Q Liu, C Ou… - Cellular Physiology and …, 2018 - karger.com
Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the
human central and peripheral nervous systems. It consists of 36 highly conserved amino …

The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour

A Farzi, F Reichmann, P Holzer - Acta Physiologica, 2015 - Wiley Online Library
Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …

Immunomodulatory role of neuropeptides in the cornea

S Puri, BM Kenyon, P Hamrah - Biomedicines, 2022 - mdpi.com
The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: A review

Y Zhang, CY Liu, WC Chen, YC Shi, CM Wang, S Lin… - Cell & Bioscience, 2021 - Springer
Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely
expressed in the central and peripheral nervous systems and acts on the cardiovascular …

TLR ligands and butyrate increase Pyy expression through two distinct but inter‐regulated pathways

P Larraufie, J Doré, N Lapaque… - Cellular …, 2017 - Wiley Online Library
The intestinal epithelium is an active barrier separating the host from its microbiota. It senses
microbial compounds through expression of a wide range of receptors including the Toll‐like …

Neuropeptide Y attenuates cardiac remodeling and deterioration of function following myocardial infarction

YY Qin, XR Huang, J Zhang, W Wu, J Chen, S Wan… - Molecular Therapy, 2022 - cell.com
Plasma levels of neuropeptide Y (NPY) are elevated in patients with acute myocardial
infarction (AMI), but its role in AMI remains unclear, which was examined here in NPY wild …

Ocular surface diabetic disease: A neurogenic condition?

A Di Zazzo, M Coassin, A Micera, T Mori, M De Piano… - The Ocular Surface, 2021 - Elsevier
Purpose To investigate clinical and inflammatory changes in the ocular surface of insulin-
dependent type I diabetic patients. Methods Two hundred and nine eyes of 106 patients with …