Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
Objective To examine region‐and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451 (previously known as …
P Lewczuk, P Riederer, SE O'bryant… - The world journal of …, 2018 - Taylor & Francis
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in …
Sporadic cerebral amyloid angiopathy (CAA) is a common age related cerebral small vessel disease, characterised by progressive deposition of amyloid-β (Aβ) in the wall of small to …
DM Walsh, DJ Selkoe - Journal of neurochemistry, 2007 - Wiley Online Library
Converging lines of evidence suggest that progressive accumulation of the amyloid β‐ protein (Aβ) plays a central role in the genesis of Alzheimer's disease, but it was long …
One of the grand challenges of biophysical chemistry is to understand the principles that govern protein misfolding and aggregation, which is a highly complex process that is …
KN Dahlgren, AM Manelli, WB Stine, LK Baker… - Journal of Biological …, 2002 - ASBMB
Genetic evidence predicts a causative role for amyloid-β (Aβ) in Alzheimer's disease. Recent debate has focused on whether fibrils (amyloid) or soluble oligomers of Aβ are the active …
O Conchillo-Solé, NS de Groot, FX Avilés, J Vendrell… - BMC …, 2007 - Springer
Background Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On …
Acutely developing lesions of the brain have been highly instructive in elucidating the neural systems underlying memory in humans and animal models. Much less has been learned …