Tumour angiogenesis is the formation of new blood vessels to support the growth of a
tumour. This process is critical for tumour progression and metastasis, making it an attractive …

The role of vascular endothelial growth factor (VEGF) in cancer cells is not limited to
angiogenesis; there are also multiple factors, such as neuropilins (non-tyrosine kinases …

Since the first discovery in 1961, more than 1300 ent-kaurane diterpenoids have been
isolated and identified from different plant sources, mainly the genus Isodon. Chemically …

Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger
angiogenesis and metastasis. As a critical orchestrate of tumorigenic conditions, hypoxia …

Eriocalyxin B (EriB), a natural ent-kaurane diterpenoid presented in the plant Isodon
eriocalyx var. laxiflora, has been reported to diminish angiogenesis-dependent breast tumor …

Increasing evidence suggests the significant contribution of high levels of thioredoxin
reductase (TrxR) in various stages of tumorigenesis and resistance to tumor chemotherapy …

Accumulating evidences have emphasized the essential roles of differentially expressed
miRNAs in papillary thyroid cancer (PTC) and follicular thyroid carcinoma (FTC) …

Angiogenesis is a process of new blood vessel formation from pre-existing vessels. Vascular
endothelial growth factor-A (VEGF-A) binds to VEGF receptor-2 (VEGFR2) and thus …

Sterols are one of the main components of medicinal fungi with an anti-tumor effect. In this
study, ergosta-4, 6, 8 (14), 22-tetraen-3-one (ET) and (22E, 24R)-ergosta-7, 22-dien-3β, 5α …

Breast cancer is the most commonly diagnosed cancer among women, and its metastasis to
distant organs accounts for the majority of death. Eriocalyxin B (Eri B), an ent-kaurane …