Current research status of HLA in immune‐related diseases
B Liu, Y Shao, R Fu - Immunity, Inflammation and Disease, 2021 - Wiley Online Library
Human leukocyte antigen (HLA), also known as human major histocompatibility complex
(MHC), is encoded by the HLA gene complex, and is currently known to have the highest …
(MHC), is encoded by the HLA gene complex, and is currently known to have the highest …
[HTML][HTML] Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities
TS Olson, BF Frost, JL Duke, M Dribus, HM Xie… - JCI insight, 2022 - ncbi.nlm.nih.gov
Acquired aplastic anemia (AA) is caused by autoreactive T cell–mediated destruction of
early hematopoietic cells. Somatic loss of human leukocyte antigen (HLA) class I alleles was …
early hematopoietic cells. Somatic loss of human leukocyte antigen (HLA) class I alleles was …
A frequent nonsense mutation in exon 1 across certain HLA-A and HLA-B alleles in leukocytes of patients with acquired aplastic anemia
H Mizumaki, K Hosomichi, K Hosokawa… - …, 2020 - pmc.ncbi.nlm.nih.gov
Leukocytes that lack expression of HLA alleles are frequently detected in patients with
acquired aplastic anemia (AA) who respond to immunosuppressive therapy, although the …
acquired aplastic anemia (AA) who respond to immunosuppressive therapy, although the …
Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria
K Hosokawa, S Nakao - Seminars in Hematology, 2022 - Elsevier
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell
disorder caused by a mutation of the X-linked PIGA gene, resulting in a deficient expression …
disorder caused by a mutation of the X-linked PIGA gene, resulting in a deficient expression …
Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia
In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated
destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no …
destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no …
Hematopoietic stem progenitor cells lacking HLA differ from those lacking GPI-anchored proteins in the hierarchical stage and sensitivity to immune attack in patients …
T Yoroidaka, K Hosokawa, T Imi, H Mizumaki… - Leukemia, 2021 - nature.com
To characterize glycosylphosphatidylinositol-anchored protein-deficient (GPI [−]) and HLA-
class I allele-lacking (HLA [−]) hematopoietic stem progenitor cells (HSPCs) in acquired …
class I allele-lacking (HLA [−]) hematopoietic stem progenitor cells (HSPCs) in acquired …
[HTML][HTML] Inducible Pluripotent Stem Cell Models to Study Bone Marrow Failure and MDS Predisposition Syndromes
Induced pluripotent stem cells (iPSCs) have emerged as powerful tools for in vitro modeling
of bone marrow failure (BMF) syndromes and hereditary conditions predisposing to …
of bone marrow failure (BMF) syndromes and hereditary conditions predisposing to …
[HTML][HTML] Recurrent disease after a matched sibling hematopoietic transplant in an aplastic anemia patient with a disease risk allele, HLA-B* 40: 02
A Khosla, Y Inoue, J Cioccio, K Rakszawski… - Blood …, 2024 - pmc.ncbi.nlm.nih.gov
Recurrent disease after a matched sibling hematopoietic transplant in an aplastic anemia
patient with a disease risk allele, HLA-B*40:02 - PMC Skip to main content Here's how you …
patient with a disease risk allele, HLA-B*40:02 - PMC Skip to main content Here's how you …
Diagnosis of immune pathophysiology in patients with bone marrow failure
S Nakao - International Journal of Hematology, 2024 - Springer
Differential diagnosis of pancytopenia with bone marrow (BM) hypoplasia represented by
aplastic anemia (AA) is often challenging for physicians, because no laboratory tests have …
aplastic anemia (AA) is often challenging for physicians, because no laboratory tests have …