Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

KRAS mutations are one of the most common oncogenic drivers in human cancer. While
small molecule inhibitors for the G12C mutant have been successfully developed, allele …

Post-translational modifications (PTMs) regulate enzyme structure and function to expand
the functional proteome. Many of these PTMs are derived from cellular metabolites and …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …

Modern next-generation sequencing-based methods have empowered researchers to assay
the epigenetic states of individual cells. Existing techniques for profiling epigenetic marks in …

Desiccation tolerance appeared as the key adaptation feature of photoautotrophic
organisms for survival in terrestrial habitats. During the further evolution, vascular plants …

Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers
forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging …