The remarkable clinical activity of chimeric antigen receptor (CAR) therapies in B cell and plasma cell malignancies has validated the use of this therapeutic class for liquid cancers …
Due to the fact that mRNA technology allows the production of diverse vaccines and treatments in a shorter time frame and with reduced expense compared to conventional …
E Baulu, C Gardet, N Chuvin, S Depil - Science Advances, 2023 - science.org
T cell engineering has changed the landscape of cancer immunotherapy. Chimeric antigen receptor T cells have demonstrated a remarkable efficacy in the treatment of B cell …
Chimeric antigen receptor (CAR) therapy has had a transformative effect on the treatment of haematologic malignancies,,,,–, but it has shown limited efficacy against solid tumours. Solid …
Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming biomedical research and providing entirely new approaches for dissecting all …
Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent …
SP Foy, K Jacoby, DA Bota, T Hunter, Z Pan, E Stawiski… - Nature, 2023 - nature.com
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells,–. Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision …
J Zhang, Y Hu, J Yang, W Li, M Zhang, Q Wang… - Nature, 2022 - nature.com
Recently, chimeric antigen receptor (CAR)-T cell therapy has shown great promise in treating haematological malignancies,,,,,–. However, CAR-T cell therapy currently has …
MTN Yarnall, EI Ioannidi, C Schmitt-Ulms… - Nature …, 2023 - nature.com
Programmable genome integration of large, diverse DNA cargo without DNA repair of exposed DNA double-strand breaks remains an unsolved challenge in genome editing. We …