This paper is the thirty-fifth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2012 …

Cell-penetrating peptides (CPPs) are a group of peptides, which have the ability to cross cell
membrane bilayers. CPPs themselves can exert biological activity and can be formed …

Although the μ opioid receptor (MOR) was pharmacologically and biochemically identified in
binding studies forty years ago, its structure, function, and true complexity only have …

Abstract The first Pd-catalyzed [5+ 2] rollover annulation of 1-benzylpyrazoles has been
developed to afford a novel class of 1H-benzo [e] furo [3, 4-c] pyrazolo [1, 5-a] azepin-3 (8H) …

Novel spiropseudoindoxyls were synthesized in high yields via a fully regioselective Au (III)-
catalyzed cycloisomerization of easily obtainable o-nitrophenylpropiolamides, followed by …

Opioid analgesics, such as morphine, oxycodone, and fentanyl, are the cornerstones for
treating moderate to severe pain. However, on chronic administration, their efficiency is …

Chronic pain is currently treated with opioids that offer unsatisfactory long-term analgesia
and produce serious side effects. There is a clear need for alternative therapies. Herein …

Constraining the conformation of flexible peptides is a proven strategy to increase potency,
selectivity, and metabolic stability. The focus has mostly been on constraining the backbone …

Derivatization of biologically active peptides by conjugation with fluorophores or
radionuclide-bearing moieties is an effective and commonly used approach to prepare …

An asymmetric construction of enantioenriched 2, 3-substituted-1-benzazepine derivatives
containing a cyclic tertiary amine moiety was developed by copper-catalyzed reductive …