While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Chronic diseases, such as obesity and diabetes, cardiovascular, and inflammatory bowel
diseases (IBD) share common features in their pathology. Metabolic disorders exhibit strong …

ABSTRACT Glucagon-like peptide 1 (GLP-1) is a target for treatment of diabetes; however,
its function in the brain is not well studied. In this systematic review, we aimed to analyze the …

Diabetes is a chronic disease leading to memory difficulties and deterioration of learning
abilities. The previous studies showed that modulation of inflammatory pathways in the …

Diabetic nephropathy (DN) is the leading cause of end-stage failure of the kidney, but the
efficacy of current strategies available for the prevention of DN remains unsatisfactory. The …

Objective. The aim of the present study was to investigate the transcriptional activity of the
GLP-1R, DPP-4, SGLT-1, INSR, and IGF-1R genes in GALT cells of rats with streptozotocin …

The transcription factor nuclear factor erythroid-2 related factor 2 (Nrf2) is a dominant
manager to inhibit oxidative and inflammatory damage. Fenretinide (Fen) is a novel agent …

Doxorubicin (DOX) is a widely used antineoplastic drug whose efficacy is limited by its
cardiotoxicity. The aim of this study was to investigate the possible protective role of the …

There is a large body of evidence suggesting that inhibitors of dipeptidyl peptidase-4, such
as sitagliptin, may exhibit beneficial effects against different inflammatory disorders. This …

Type 1 diabetes mellitus (T1DM) describes a complex group of metabolic disorders
associated with elevated blood glucose levels and increased risks of complications …