Modeling of normal tissue complications using imaging and biomarkers after radiation therapy for hepatocellular carcinoma

I El Naqa, A Johansson, D Owen, K Cuneo… - International Journal of …, 2018 - Elsevier
Purpose To develop normal tissue complications (NTCP) models for hepatocellular cancer
(HCC) patients who undergo liver radiation therapy (RT) and to evaluate the potential role of …

The effect of stereotactic body radiation therapy for hepatocellular cancer on regional hepatic liver function

L Wei, J Simeth, MP Aryal, M Matuszak… - International Journal of …, 2023 - Elsevier
Purpose To investigate direct radiation dose–related and inflammation-mediated regional
hepatic function losses after stereotactic body radiation therapy (SBRT) in patients with …

PET/CT-Based Absorbed Dose Maps in 90Y Selective Internal Radiation Therapy Correlate with Spatial Changes in Liver Function Derived from Dynamic MRI

Z Lu, DF Polan, L Wei, MP Aryal… - Journal of Nuclear …, 2024 - jnm.snmjournals.org
Functional liver parenchyma can be damaged from treatment of liver malignancies with 90Y
selective internal radiation therapy (SIRT). Evaluating functional parenchymal changes and …

Modeling dynamic radial contrast enhanced MRI with linear time invariant systems for motion correction in quantitative assessment of kidney function

J Coll-Font, O Afacan, JS Chow, RS Lee… - Medical image …, 2021 - Elsevier
Early identification of kidney function deterioration is essential to determine which newborn
patients with congenital kidney disease should be considered for surgical intervention as …

Quantification of liver function by linearization of a two‐compartment model of gadoxetic acid uptake using dynamic contrast‐enhanced magnetic resonance imaging

J Simeth, A Johansson, D Owen, K Cuneo… - NMR in …, 2018 - Wiley Online Library
Dynamic gadoxetic acid‐enhanced magnetic resonance imaging (MRI) allows the
investigation of liver function through the observation of the perfusion and uptake of contrast …

Abdominal DCE‐MRI reconstruction with deformable motion correction for liver perfusion quantification

A Johansson, JM Balter, Y Cao - Medical physics, 2018 - Wiley Online Library
Purpose Abdominal dynamic contrast‐enhanced (DCE) MRI suffers from motion‐induced
artifacts that can blur images and distort contrast‐agent uptake curves. For liver perfusion …

Rigid‐body motion correction of the liver in image reconstruction for golden‐angle stack‐of‐stars DCE MRI

A Johansson, J Balter, Y Cao - Magnetic resonance in …, 2018 - Wiley Online Library
Purpose Respiratory motion can affect pharmacokinetic perfusion parameters quantified
from liver dynamic contrast‐enhanced MRI. Image registration can be used to align dynamic …

Deep learning prediction of post‐SBRT liver function changes and NTCP modeling in hepatocellular carcinoma based on DGAE‐MRI

L Wei, MP Aryal, K Cuneo, M Matuszak… - Medical …, 2023 - Wiley Online Library
Background Stereotactic body radiation therapy (SBRT) produces excellent local control for
patients with hepatocellular carcinoma (HCC). However, the risk of toxicity for normal liver …

GAN and dual‐input two‐compartment model‐based training of a neural network for robust quantification of contrast uptake rate in gadoxetic acid‐enhanced MRI

J Simeth, Y Cao - Medical physics, 2020 - Wiley Online Library
Purpose Gadoxetic acid uptake rate (k1) obtained from dynamic, contrast‐enhanced (DCE)
magnetic resonance imaging (MRI) is a promising measure of regional liver function …

Quantifying Regional and Global Liver Function Via Gadoxetic Acid Uptake

J Simeth - 2020 - deepblue.lib.umich.edu
Liver function is a dominant factor in the survival of patients with hepatocellular carcinoma
(HCC). Measures of regional and global liver function are critical in guiding treatments for …