Cigarette smoking is associated with numerous diseases and poses a serious challenge to
the current healthcare system worldwide. Smoking impacts both innate and adaptive …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Carbon monoxide (CO) is an endogenously produced gas that has gained recognition as a
biological signal transduction effector with properties similar, but not identical, to that of nitric …

Evidence now points to the haeme oxygenase (HO) pathway as a possible actor in
modulating risk for cardiovascular disease (CVD). In particular, the HO pathway may …

Dendritic cells (DCs) play a key role in the activation of the immune response against
pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags) …

Gaseous molecules continue to hold new promise in molecular medicine as experimental
and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar …

Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form
carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an …

Aims/hypothesis Recent studies have identified carbon monoxide (CO) as a potential
therapeutic molecule for the treatment of autoimmune diseases owing to its anti …

Background Carbon monoxide (CO) is an important signaling molecule participating in
multiple biological functions. Previous studies have confirmed the valuable roles of CO in …

Type 1 diabetes (T1D) is a T cell mediated autoimmune disease characterized by immune
mediated destruction of the insulin-producing β cells in the islets of Langerhans. Dendritic …