Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Analysis of the clinical pipeline of treatments for drug-resistant bacterial infections: despite progress, more action is needed

MS Butler, V Gigante, H Sati, S Paulin… - Antimicrobial agents …, 2022 - Am Soc Microbiol
There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

[HTML][HTML] The spread of antibiotic resistance to humans and potential protection strategies

D Ding, B Wang, X Zhang, J Zhang, H Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome

A Crits-Christoph, HA Hallowell, K Koutouvalis… - Gut …, 2022 - Taylor & Francis
ABSTRACT A global rise in antimicrobial resistance among pathogenic bacteria has proved
to be a major public health threat, with the rate of multidrug-resistant bacterial infections …

Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection

A Yadegar, S Pakpoor, FF Ibrahim, A Nabavi-Rad… - Cell host & …, 2023 - cell.com
Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent
Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical …

Safety of fecal microbiota, live-jslm (REBYOTA) in individuals with recurrent Clostridioides difficile infection: data from five prospective clinical trials

C Lee, T Louie, L Bancke… - Therapeutic …, 2023 - journals.sagepub.com
Background: Microbiota-based treatments reduce the incidence of recurrent Clostridioides
difficile infections (rCDIs), but prospectively collected safety data needed to broaden patient …

The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection

AM Seekatz, N Safdar… - Therapeutic Advances in …, 2022 - journals.sagepub.com
The species composition of the human gut microbiota is related to overall health, and a
healthy gut microbiome is crucial in maintaining colonization resistance against pathogens …

Gut microbiota changes associated with Clostridioides difficile infection and its various treatment strategies

AJ Gonzales-Luna, TJ Carlson, KW Garey - Gut Microbes, 2023 - Taylor & Francis
Human gut microbiota are critical to both the development of and recovery from
Clostridioides difficile infection (CDI). Antibiotics are the mainstay of CDI treatment, yet …

[HTML][HTML] Antibiotic resistance monitoring in wastewater in the Nordic countries: A systematic review

A Tiwari, A Krolicka, TT Tran, K Räisänen… - Environmental …, 2024 - Elsevier
Abstract The Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden) have
effectively kept lower antibiotic-resistant bacterial (ARB) pathogen rates than many other …

Impact of international travel and diarrhea on gut microbiome and resistome dynamics

M Boolchandani, KS Blake, DH Tilley… - Nature …, 2022 - nature.com
International travel contributes to the global spread of antimicrobial resistance. Travelers'
diarrhea exacerbates the risk of acquiring multidrug-resistant organisms and can lead to …