Linear nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs)
template the modular biosynthesis of numerous nonribosomal peptides, polyketides and …

Molecules containing bipyridine scaffold are fascinating and versatile compounds in the field
of natural product chemistry and drug discovery, and these molecules have possible …

Caerulomycin A (CRM A 1) belongs to a family of natural products containing a 2, 2′-
bipyridyl ring core structure and is currently under development as a potent novel …

Caerulomycins are a family of natural alkaloids featuring a 2, 2′-bipyridine nucleus. Since
the first example of caerulomycins, caerulomycin A from Streptomyces caeruleus, was …

Background and Purpose Recently, we have described the use of caerulomycin A (CaeA) as
a potent novel immunosuppressive agent. Immunosuppressive drugs are crucial for long …

Background Activation of silent biosynthetic gene clusters (BGCs) in marine-derived
actinomycete strains is a feasible strategy to discover bioactive natural products …

Substrate salvage or recycling is common and important for primary metabolism in cells but
is rare in secondary metabolism. Herein we report flavoenzyme CrmK-mediated shunt …

In this study, we characterized CaeB6 as a selective hydroxylase and CaeG1 as an O-
methyltransferase in the biosynthesis of the 2, 2′-bipyridine natural products caerulomycins …

Here, we report a two-component enzymatic system that efficiently catalyzes the reduction of
a carboxylate to an aldehyde in the biosynthesis of 2, 2′-bipyridine antibiotics …

Background Caerulomycin A (CaeA) is a known antifungal and antibiotic agent. Further,
CaeA is reported to induce the expansion of regulatory T cell and prolongs the survival of …