All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Morphogenesis, the process by which tissues develop into functional shapes, requires
coordinated mechanical forces. Most current literature ascribes contractile forces derived …

Aggregates of stem cells can break symmetry and self-organize into embryo-like structures
with complex morphologies and gene expression patterns. Mechanisms including reaction …

The epithelial and interstitial stem cells of the freshwater polyp Hydra are the best-
characterized stem cell systems in any cnidarian, providing valuable insight into cell type …

Epithelial tissues sheath organs and electro-mechanically regulate ion and water transport
to regulate development, homeostasis, and hydrostatic organ pressure. Here, we …

Understanding complex living systems, which are fundamentally constrained by physical
phenomena, requires combining experimental data with theoretical physical and …

The WNT signaling pathway plays a critical role in a variety of biological processes,
including development, adult tissue homeostasis maintenance, and stem cell regulation …

The molecular mechanisms that maintain cellular identities and prevent dedifferentiation or
transdifferentiation remain mysterious. However, both processes are transiently used during …

Multicellular systems grow over the course of weeks from single cells to tissues or even full
organisms, making live imaging challenging. To bridge spatiotemporal scales, we present …

The development and origin of animal body forms have long been intensely explored, from
the analysis of morphological traits during antiquity to Newtonian mechanical conceptions of …