Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development

FS PapeVeronika, A EnyedyÉva… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

In vitro and in vivo anticancer activity of copper bis (thiosemicarbazone) complexes

D Palanimuthu, SV Shinde… - Journal of medicinal …, 2013 - ACS Publications
Neutral and cationic copper bis (thiosemicarbazone) complexes bearing methyl, phenyl, and
hydrogen, on the diketo-backbone of the ligand have been synthesized. All of them were …

Design, synthesis, and characterization of novel iron chelators: Structure− activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3 …

DS Kalinowski, Y Yu, PC Sharpe, M Islam… - Journal of medicinal …, 2007 - ACS Publications
Previously, we demonstrated that the potent antiproliferative activity of the di-2-pyridylketone
thiosemicarbazone (DpT) series of Fe chelators was due to their ability to induce Fe …

Studies on the effect of metal ions of hydrazone complexes on interaction with nucleic acids, bovine serum albumin and antioxidant properties

P Sathyadevi, P Krishnamoorthy, E Jayanthi… - Inorganica Chimica …, 2012 - Elsevier
Three new transition metal complexes of the type ML2 (where M= Ni (II), Co (II) or Cu (II);
HL= N′-[phenyl (pyridin-2-yl) methylidene] furan-2-carbohydrazide]) have been prepared …

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation

CR Kowol, R Trondl, P Heffeter, VB Arion… - Journal of medicinal …, 2009 - ACS Publications
The first metal complexes of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone
(Triapine) were synthesized. Triapine was prepared by a novel three-step procedure in 64 …

Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity

PV Bernhardt, PC Sharpe, M Islam… - Journal of medicinal …, 2009 - ACS Publications
We previously reported a series of di-2-pyridylketone thiosemicarbazone (H DpT) chelators
that showed marked and selective antitumor activity (Whitnall, M.; et al. Proc. Natl. Acad. Sci …

Copper (II) complexes of N (4)-substituted thiosemicarbazones derived from pyridine-2-carbaldehyde: Crystal structure of a binuclear complex

PF Rapheal, E Manoj, MRP Kurup - Polyhedron, 2007 - Elsevier
Ten copper (II) complexes {[CuL1Cl](1),[CuL1NO3] 2 (2),[CuL1N3] 2· 2/3H2O (3),[CuL1] 2
(ClO4) 2· 2H2O (4),[CuL2Cl] 2 (5),[CuL2N3](6),[Cu (HL2) SO4] 2· 4H2O (7),[Cu (HL2) …

Synthesis, spectroscopic characterizations, single crystal X-ray analysis, DFT calculations, in vitro biological evaluation and in silico evaluation studies of …

VNV Palakkeezhillam, J Haribabu… - Journal of Molecular …, 2023 - Elsevier
We created new thiosemicarbazones and their cyclized heterocyclic compounds, examined
them, and evaluated their biological activity in silico and in vitro. Two pyrene-based …

In-situ fixation of all-inorganic Mo–Fe–S clusters for the highly selective removal of lead (II)

W Zhang, S Shi, W Zhu, C Yang, S Li… - … applied materials & …, 2017 - ACS Publications
The selective adsorption by suitable substrate materials is considered one of the most
economical methods. In this work, an all-inorganic bimetallic Mo–Fe–S cluster is facilely …

Copper, nickel and zinc complexes of 3-acetyl coumarin thiosemicarbazone: Synthesis, characterization and in vitro evaluation of cytotoxicity and DNA/protein binding …

KNA Rahman, J Haribabu, C Balachandran… - Polyhedron, 2017 - Elsevier
A new 3-acetylcoumarin thiosemicarbazone (AcTsc) and its copper (II)(1), nickel (II)(2) and
zinc (II)(3) complexes were synthesized and characterized by elemental analysis, UV–Vis …