Quinoline-based hybrid compounds with antimalarial activity

X Nqoro, N Tobeka, BA Aderibigbe - Molecules, 2017 - mdpi.com
The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

Parasite powerhouse: A review of the Toxoplasma gondii mitochondrion

MM Usey, D Huet - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
Toxoplasma gondii is a member of the apicomplexan phylum, a group of single‐celled
eukaryotic parasites that cause significant human morbidity and mortality around the world …

Participation of Oxidative Stress in the Activity of Compounds Isolated from Eleutherine plicata Herb

ARQ Gomes, JN Cruz, ALG Castro… - Molecules, 2023 - mdpi.com
From Eleutherine plicata, naphthoquinones, isoeleutherine, and eleutherol were isolated,
and previous studies have reported the antioxidant activity of these metabolites. The present …

Malaria molecular surveillance in the Peruvian Amazon with a novel highly multiplexed Plasmodium falciparum AmpliSeq assay

JH Kattenberg, C Fernandez-Miñope… - Microbiology …, 2023 - Am Soc Microbiol
Molecular surveillance for malaria has great potential to support national malaria control
programs (NMCPs). To bridge the gap between research and implementation, several …

Withanolide A offers neuroprotection, ameliorates stress resistance and prolongs the life expectancy of Caenorhabditis elegans

BA Akhoon, S Pandey, S Tiwari, R Pandey - Experimental gerontology, 2016 - Elsevier
Withanolide A (steroidal lactone) forms the major constituent of the most popular herbal drug
in Ayurvedic medicine, Ashwagandha. It has been used since ancient times as an …

High-throughput quantitative glycomics enabled by 12-plex isobaric multiplex labeling reagents for carbonyl-containing compound (SUGAR) tags

M Li, Y Feng, M Ma, A Kapur… - Journal of proteome …, 2023 - ACS Publications
Glycans, which are widely distributed on most proteins and cell surfaces, are a class of
important biomolecules playing crucial roles in various biological processes such as …

Discovery of a new donepezil-like acetylcholinesterase inhibitor for targeting Alzheimer's disease: computational studies with biological validation

BA Akhoon, S Choudhary, H Tiwari… - Journal of Chemical …, 2020 - ACS Publications
Alzheimer's disorder is one of the most common worldwide health problems, and its
prevalence continues to increase, thereby straining the healthcare budgets of both …

Structural dynamics of Casein Kinase I (CKI) from malarial parasite Plasmodium falciparum (Isolate 3D7): Insights from theoretical modelling and molecular …

B Dehury, SK Behera, N Mahapatra - Journal of molecular graphics and …, 2017 - Elsevier
The protein kinases (PKs), belonging to serine/threonine kinase (STKs), are important drug
targets for a wide spectrum of diseases in human. Among protein kinases, the Casein …

Correlated motions and dynamics in different domains of epidermal growth factor receptor with L858R and T790M mutations

R Qureshi, A Ghosh, H Yan - IEEE/ACM Transactions on …, 2020 - ieeexplore.ieee.org
Non-small cell lung cancer with an activating epidermal growth factor receptor (EGFR)
mutation responds well to targeted drugs. In most cases, drug resistance appears after about …

An epigrammatic status of the 'azole'-based antimalarial drugs

M Sharma, P Prasher - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
The development of multidrug resistance in the malarial parasite has sabotaged majority of
the eradication efforts by restraining the inhibition profile of first line as well as second line …