BMP signaling is one of the key pathways regulating craniofacial development. It is involved
in the early patterning of the head, the development of cranial neural crest cells, and facial …

Periodontitis is a widespread inflammatory disease that leads to loss of the tooth supporting
periodontal tissues. The few therapies available to regenerate periodontal tissues have high …

Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem
cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as …

Aims Kaempferol, a type of flavonoid, is widely present in fruits, vegetables and medicinal
herbs. This study was designed to investigate the effects of kaempferol on proliferation and …

MicroRNAs (miRNAs) are a group of small RNAs that control gene expression in all aspects
of eukaryotic life, primarily through RNA silencing mechanisms. The purpose of the present …

Pulp loss is accompanied by the functional impairment of defense, sensory, and nutrition
supply. The approach based on endogenous stem cells is a potential strategy for pulp …

Bivalves, from raw oysters to steamed clams, are popular choices among seafood lovers
and once limited to the coastal areas. The rapid growth of the aquaculture industry and …

Background Periodontitis is a chronic infection initiated by oral bacterial and their virulence
factors, yet the severity of periodontitis is largely determined by the dysregulated host …

Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by
important signaling pathways such as Wnt and BMP signaling. Serious injuries and/or loss …

Cell fate commitment is controlled by cis-regulatory elements often located in remote regions
of the genome. To examine the role of long-range DNA interactions in early development …