In December 2019, a pneumonia outbreak was reported in Wuhan, Hubei province, China.
Since then, the World Health Organization declared a public health emergency of …

Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors that
participate in the regulation of key events of development, disease, and tissue repair. In the …

Background Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a
cascade of pathological changes in Alzheimer's disease (AD), and inhibiting BACE1, which …

Previous studies show that 3β-hydroxysterol-Δ24 reductase (DHCR24) has a remarked
decline in the brain of AD patients. In brain cholesterol synthetic metabolism, DHCR24 is …

Glial cells, including astrocytes, oligodendrocytes, and microglia, are the major components
in the central nervous system (CNS). Studies have revealed the heterogeneity of each glial …

The synthetase 3β-hydroxysterol-Δ24 reductase (DHCR24) is a key regulator involved in
cholesterol synthesis and homeostasis. A growing body of evidence indicates that DHCR24 …

Astrocyte heterogeneity and its relation to aging in the normal human brain remain poorly
understood. We here analyzed astrocytes in gray and white matter brain tissues obtained …

Ageing is associated with a morphological and functional decline of astrocytes with a
prevalence of morphological atrophy and loss of function. In particular, ageing is manifested …

Abstract Adult Premature Aging Mice (PAM) show premature immunosenescence, oxidative
and inflammatory stress and consequently a shorter lifespan than Exceptional Non …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disease in
which multiple cell types and cellular pathways play a role. A pathological hallmark of …