The biology of mucus: Composition, synthesis and organization

R Bansil, BS Turner - Advanced drug delivery reviews, 2018 - Elsevier
In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing
cells that lines the epithelial surfaces of all organs exposed to the external world. Mucus is a …

[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery

J Leal, HDC Smyth, D Ghosh - International journal of pharmaceutics, 2017 - Elsevier
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Mucins and their role in shaping the functions of mucus barriers

CE Wagner, KM Wheeler… - Annual review of cell and …, 2018 - annualreviews.org
We review what is currently understood about how the structure of the primary solid
component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical …

Acidic pH increases airway surface liquid viscosity in cystic fibrosis

XX Tang, LS Ostedgaard, MJ Hoegger… - The Journal of …, 2016 - Am Soc Clin Investig
Cystic fibrosis (CF) disrupts respiratory host defenses, allowing bacterial infection,
inflammation, and mucus accumulation to progressively destroy the lungs. Our previous …

Mucin structure, aggregation, physiological functions and biomedical applications

R Bansil, BS Turner - Current opinion in colloid & interface science, 2006 - Elsevier
An understanding of the basic structure, viscoelastic properties and interactions of mucin
glycoproteins is of considerable interest to food science because of the important protective …

Helicobacter pylori moves through mucus by reducing mucin viscoelasticity

JP Celli, BS Turner, NH Afdhal… - Proceedings of the …, 2009 - National Acad Sciences
The ulcer-causing gastric pathogen Helicobacter pylori is the only bacterium known to
colonize the harsh acidic environment of the human stomach. H. pylori survives in acidic …

Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin

A Allen, G Flemström - American Journal of Physiology …, 2005 - journals.physiology.org
Secretion of bicarbonate into the adherent layer of mucus gel creates a pH gradient with a
near-neutral pH at the epithelial surfaces in stomach and duodenum, providing the first line …

Saliva as research material: biochemical, physicochemical and practical aspects

RG Schipper, E Silletti, MH Vingerhoeds - Archives of oral biology, 2007 - Elsevier
Whole saliva is a complex mixture of proteins and other molecules which originate from
several sources. The biochemical and physicochemical properties of saliva contribute to the …

[HTML][HTML] Models for oral uptake of nanoparticles in consumer products

E Fröhlich, E Roblegg - Toxicology, 2012 - Elsevier
Presently, many consumer products contain nano-sized materials (NMs) to improve material
properties, product quality and ease of use. NMs in food additives and in cosmetic articles …

[PDF][PDF] Mucin biophysics

R Bansil, E Stanley, JT LaMont - Annual review of physiology, 1995 - researchgate.net
Mucus, the slimy, viscous secretion that covers epithelial surfaces throughout the body,
contains water, salts, immunoglobulins, secreted proteins, and mucin. Mucus ecretions are …