Siglec-15 as an emerging target for next-generation cancer immunotherapy

J Sun, Q Lu, MF Sanmamed, J Wang - Clinical Cancer Research, 2021 - AACR
Immunomodulatory agents blocking the PD-1/PD-L1 pathway have shown a new way to
treat cancer. The explanation underlying the success of these agents may be the selective …

Association of Sialic Acid–Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant …

S Zhou, Y Wang, R Zhang, W Zeng, S Liu… - JAMA Network …, 2023 - jamanetwork.com
Importance Sialic acid–binding immunoglobulin-like lectin 15 (Siglec-15) is a novel immune
checkpoint molecule that is highly homologous to programmed cell death ligand 1 (PD-L1) …

[HTML][HTML] Tumor stroma Siglec15 expression is a poor prognosis predictor in colon adenocarcinoma

W Zhan, F Bai, Y Cai, J Zhang, G Qin, Y Xie… - Journal of …, 2023 - ncbi.nlm.nih.gov
Sialic acid binding Ig-like lectin 15 (Siglec15) is considered a novel immune checkpoint and
an emerging target for next-generation cancer immunotherapy. However, the significance of …

[HTML][HTML] Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer

X Cao, Y Zhou, F Mao, Y Lin, X Zhou, Q Sun - International …, 2022 - Elsevier
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec15) is an immune checkpoint
molecule that can inhibit T cell proliferation and have anti-tumor immunity. We explored the …

[PDF][PDF] Siglec-15 抗体在非小细胞肺癌中的调控机制研究

李延康, 贺钢枫 - 中国比较医学杂志, 2023 - zgbjyx.cnjournals.com
唾液酸结合免疫球蛋白样凝集素-15 (sialic acid-binding immunoglobulin-like lectin, Siglec-15)
作为新发现的一种免疫检查点抑制剂(immune checkpoint inhibitors, ICIs) …