Behaviours of complex biomolecular systems are often irreducible to the elementary
properties of their individual components. Explanatory and predictive mathematical models …

Genetic changes and environmental differences result in cellular heterogeneity among
cancer cells within the same tumor, thereby complicating treatment outcomes. Recent …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

Inferring gene regulatory networks (GRNs) based on gene expression profiles is able to
provide an insight into a number of cellular phenotypes from the genomic level and reveal …

Transcription factor (TF) networks are thought to regulate embryonic stem cell (ESC)
pluripotency. However, TF expression dynamics and regulatory mechanisms are poorly …

Detailed insights into the biological functions of the liver and an understanding of its
crosstalk with other human tissues and the gut microbiota can be used to develop novel …

Adult blood contains a mixture of mature cell types, each with specialized functions. Single
hematopoietic stem cells (HSCs) have been functionally shown to generate all mature cell …

Single-cell RNA-sequencing (scRNA-seq) enables high-throughput measurement of RNA
expression in single cells. However, because of technical limitations, scRNA-seq data often …

Background Reconstruction of executable mechanistic models from single-cell gene
expression data represents a powerful approach to understanding developmental and …

Transcription factor (TF) networks are a key determinant of cell fate decisions in mammalian
development and adult tissue homeostasis and are frequently corrupted in disease …