The moniker lysophospholipid incorporates two broad families of membrane-derived lipids:
the glycerophospholipids and the sphingolipids. 1 Primary representatives of these two arms …

The oral sphingosine 1-phosphate (S1P) receptor (S1PR) modulator fingolimod has been
shown to be effective in the treatment of patients with relapsing multiple sclerosis (MS). The …

Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained
from ceramide. S1P is known to be an important signaling molecule and plays multiple roles …

Outcomes for lung transplantation are the worst of any solid organ, and ischemia-
reperfusion injury (IRI) limits both short-and long-term outcomes. Presently no therapeutic …

The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised
of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The …

This study investigated the effects of ponesimod, a selective S1P1 receptor modulator, on T
lymphocyte subsets in 16 healthy subjects. Lymphocyte subset proportions and absolute …

Immune complex-induced acute lung injury (IC-ALI) has been implicated in various
pulmonary disease states. However, the role of NKT cells in IC-ALI remains unknown …

Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and
targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from …

Accumulating research indicates that B cells are involved in anti-tumor immunity. Chronic
alcohol consumption is associated with decreased survival of cancer patients. The effect of …

Objectives Natural killer T (NKT) cells are unique T lymphocytes that recognize glycolipid
antigen and produce various cytokines. NKT cells accelerate atherosclerosis in mice …