Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …
New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects
M Huang, Y Lin, C Wang, L Deng, M Chen… - Drug resistance …, 2022 - Elsevier
Angiogenesis is a hallmark of cancer and is required for tumor growth and progression.
Antiangiogenic therapy has been revolutionarily developing and was approved for the …
Antiangiogenic therapy has been revolutionarily developing and was approved for the …
Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy
A biodegradable drug delivery system (DDS) is one the most promising therapeutic
strategies for cancer therapy. Here, we propose a unique concept of light activation of black …
strategies for cancer therapy. Here, we propose a unique concept of light activation of black …
Cancer metastasis: molecular mechanisms and clinical perspectives
Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …
shapes the course of disease for cancer patients and commonly determines its lethal …
Tumor cell intravasation
SPH Chiang, RM Cabrera… - American Journal of …, 2016 - journals.physiology.org
The process of entering the bloodstream, intravasation, is a necessary step in the
development of distant metastases. The focus of this review is on the pathways and …
development of distant metastases. The focus of this review is on the pathways and …
Cancer lipid metabolism confers antiangiogenic drug resistance
Intrinsic and evasive antiangiogenic drug (AAD) resistance is frequently developed in
cancer patients, and molecular mechanisms underlying AAD resistance remain largely …
cancer patients, and molecular mechanisms underlying AAD resistance remain largely …
Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models
C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …
Specific gut microbiome signature predicts the early-stage lung cancer
Alterations of gut microbiota have been implicated in multiple diseases including cancer.
However, the gut microbiota spectrum in lung cancer remains largely unknown. Here we …
However, the gut microbiota spectrum in lung cancer remains largely unknown. Here we …
Targeting endothelial permeability in the EPR effect
The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …
Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non …
PM Lacal, G Graziani - Pharmacological research, 2018 - Elsevier
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …