Low-cost microfluidic systems for detection of neglected tropical diseases

KMP Pinheiro, BGS Guinati, NS Moreira… - Annual Review of …, 2023 - annualreviews.org
Neglected tropical diseases (NTDs) affect tropical and subtropical countries and are caused
by viruses, bacteria, protozoa, and helminths. These kinds of diseases spread quickly due to …

Engineered In Vitro Models to Improve the Mechanistic Understanding and Treatment of Neglected Tropical Diseases Caused by Protozoan Parasites

T Monjure, J Rosero, JA Ruley, AJ Hernandez… - GEN …, 2024 - liebertpub.com
Neglected tropical diseases (NTDs), particularly those caused by trypanosomatid protozoa,
impose a significant global burden, disproportionately affecting underserved communities in …

Spatial confinement of Trypanosoma brucei in microfluidic traps provides a new tool to study free swimming parasites

M De Niz, E Frachon, S Gobaa, P Bastin - Plos one, 2023 - journals.plos.org
Trypanosoma brucei is the causative agent of African trypanosomiasis and is transmitted by
the tsetse fly (Glossina spp.). All stages of this extracellular parasite possess a single …

Lab on a chip (LOC) platform for drug screening against the intracellular forms of Trypanosoma cruzi

MF Cadena, G Rosero-Yanez, R Isa-Jara… - Microchemical …, 2024 - Elsevier
Trypanosoma cruzi is the etiological agent of Chagas disease, endemic in Latin America
with recent spreading to non-endemic areas due to human migration. The low efficacy and …

Confining Trypanosoma brucei in emulsion droplets reveals population variabilities in division rates and improves in vitro cultivation

SH Oldenburg, L Buisson, T Beneyton, D Pekin… - Scientific Reports, 2021 - nature.com
Trypanosome parasites are infecting mammals in Sub-Saharan Africa and are transmitted
between hosts through bites of the tsetse fly. The transmission from the insect vector to the …

Revealing spatio-temporal dynamics with long-term trypanosomatid live-cell imaging

RS Muniz, PC Campbell, TE Sladewski… - PLoS …, 2022 - journals.plos.org
Trypanosoma brucei, the causative agent of human African trypanosomiasis, is highly motile
and must be able to move in all three dimensions for reliable cell division. These …

TrypanoFluidique: compartimentation, culture et analyse de la microfluidique de gouttes de Trypanosoma brucei

S Oldenburg - 2021 - theses.hal.science
Trypanosoma brucei are protozoan parasites infecting mammals in Sub-Saharan Africa
causing the disease known as Sleeping sickness. The parasites are transmitted between the …

A Fret Flow Cytometry-Based Screening Assay for Multiplex Analysis of Metabolites in T. brucei

RA Zegarra - 2021 - scholarsarchive.byu.edu
Kinetoplastid parasites are a significant public health issue in some tropical and subtropical
regions of the world. Kinetoplastid parasites all require glycolysis for survival, with host …