The next frontier in immunotherapy: potential and challenges of CAR-macrophages

J Li, P Chen, W Ma - Experimental Hematology & Oncology, 2024 - Springer
Chimeric antigen receptor macrophage (CAR-MΦ) represents a significant advancement in
immunotherapy, especially for treating solid tumors where traditional CAR-T therapies face …

Fatty acid oxidation in immune function

F Kemp, EL Braverman, CA Byersdorfer - Frontiers in immunology, 2024 - frontiersin.org
Cellular metabolism is a crucial determinant of immune cell fate and function. Extensive
studies have demonstrated that metabolic decisions influence immune cell activation …

(Multi-) omics studies of ILC2s in inflammation and metabolic diseases

M Kral, EPC van der Vorst, C Weber… - Frontiers in Cell and …, 2024 - frontiersin.org
Type 2 innate lymphoid cells (ILC2s) have emerged as pivotal regulators in the
pathogenesis of diseases, with their roles in inflammation, metabolism, and tissue …

Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management

V Mocanu, DV Timofte, CM Zară-Dănceanu, L Labusca - Biomedicines, 2024 - mdpi.com
Osteoarthritis (OA) is a progressive chronic disease affecting the articular joints, leading to
pain and disability. Unlike traditional views that primarily link OA to aging, recent …

Will AMPK be a potential therapeutic target for hepatocellular carcinoma?

G Chen, MY Li, JY Yang… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Cancer is the disease that poses the greatest threat to human health today. Among them,
hepatocellular carcinoma (HCC) is particularly prominent due to its high recurrence rate and …

[HTML][HTML] Exploring the Impact of Personalized Nutritional Approaches on Metabolism and Immunity: A Systematic Review of Various Nutrients and Dietary Patterns

CN Paulsingh, MF Riaz, G Garg, L Umeano, S Iftikhar… - Cureus, 2024 - ncbi.nlm.nih.gov
The systematic review investigates the impact of different nutrients and dietary patterns on
metabolism and immunity to answer the research question:" Can personalized nutritional …

Mitochondrial Dysfunction and Immune Dysregulation in Primary Sjogren's Syndrome: Implications for Therapeutic Strategies

AV Poznyak, NA Orekhov… - Journal of …, 2024 - publishing.emanresearch.org
Primary Sjogren's syndrome (SjS) is a complex autoimmune disorder characterized by dry
eye syndrome, xerostomia, and systemic manifestations, significantly impacting patients' …