Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

A Campaniço, R Moreira, F Lopes - European journal of medicinal …, 2018 - Elsevier
Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …

Tuberculosis: The success tale of less explored dormant Mycobacterium tuberculosis

A Verma, A Ghoshal, VP Dwivedi… - Frontiers in Cellular and …, 2022 - frontiersin.org
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that predominantly affects
the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and …

Mycobacterial tuberculosis enzyme targets and their inhibitors

AK Saxena, A Singh - Current Topics in Medicinal Chemistry, 2019 - ingentaconnect.com
Tuberculosis (TB) still continues to be a major killer disease worldwide. Unlike other bacteria
Mycobacterium tuberculosis (Mtb) has the ability to become dormant within the host and to …

Targeting Non-Replicating Mycobacterium tuberculosis and Latent Infection: Alternatives and Perspectives (Mini-Review)

A Egorova, EG Salina, V Makarov - International Journal of Molecular …, 2021 - mdpi.com
Latent tuberculosis infection (LTBI) represents a major challenge to curing TB disease.
Current guidelines for LTBI management include only three older drugs and their …

The zebrafish model of tuberculosis-no lungs needed

G Bouz, N Al Hasawi - Critical reviews in microbiology, 2018 - Taylor & Francis
Tuberculosis is still a global health burden. It is caused by Mycobacterium tuberculosis
which afflicts around one third of the world's population and costs around 1.3 million people …

The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development

W Yan, Y Zheng, C Dou, G Zhang, T Arnaout… - Molecular …, 2022 - Springer
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a tenacious
pathogen that has latently infected one third of the world's population. However …

Mycobacterium tuberculosis lysine-ɛ-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors

RS Reshma, VU Jeankumar, N Kapoor… - Bioorganic & Medicinal …, 2017 - Elsevier
MTB lysine-ɛ-aminotransferase (LAT) was found to play a crucial role in persistence and
antibiotic tolerance. LAT serves as a potential target in the management of latent …

Addressing latent tuberculosis: New advances in mimicking the disease, discovering key targets, and designing hit compounds

A Campaniço, SG Harjivan, DF Warner… - International Journal of …, 2020 - mdpi.com
Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB)
remains a global public health concern arch. Our inability to eradicate this bacillus is …

Latent tuberculosis infection (LTBI) and its potential targets: an investigation into dormant phase pathogens

G Gutti, K Arya, SK Singh - Mini reviews in medicinal chemistry, 2019 - ingentaconnect.com
One-third of the world's population harbours the latent tuberculosis infection (LTBI) with a
lifetime risk of reactivation. Although, the treatment of LTBI relies significantly on the first-line …

Important Targets and Inhibitors of Mycobacterium tuberculosis

S Nandi, M Saxena, AK Saxena - Tuberculosis: Integrated Studies for a …, 2023 - Springer
Tuberculosis (TB) is a global health issue. Millions of TB-infected patients remain
undiagnosed, untreated, or improperly treated, leading to recurrence, re-infection, and …