As simulation is playing an increasingly important role in medicine, providing the individual
patient with a customised diagnosis and treatment is envisaged as part of future precision …

The use of in silico models to improve our understanding of the fluid dynamics within the
gastrointestinal tract has increased over the last few decades. Computational fluid dynamics …

The performance of solid oral dosage forms targeting the colon is typically evaluated using
standardised pharmacopeial dissolution apparatuses. However, these fail to replicate …

Objective. Neural regulation of gastric motility occurs partly through the regulation of gastric
bioelectrical slow waves (SWs) and phasic contractions. The interaction of the tissues and …

The stomach is extensively innervated by the vagus nerve and the enteric nervous system.
The mechanisms through which this innervation affects gastric motility are being unraveled …

This study proposes a hybrid approach for combining mechanistic (first principle) and
Machine Learning models. This approach applies to discrete (particle-based) systems and …

This work proposes a model of particle agglomeration in elastic valves replicating the
geometry and the fluid dynamics of a venous valve. The fluid dynamics is simulated with …

The Dynamic Colon Model (DCM) is an advanced in vitro model of the human proximal
colon. This thesis takes an existing DCM through design, development and validation work …

Advancements in hardware have enabled more sophisticated computational models that
facilitate mechanistic studies through simulations of various interventions both in vivo and ex …

This work proposes a model of particle agglomeration in elastic valves replicating the
geometry and the fluid dynamics of a venous valve. The fluid dynamics is simulated with …