Obesity and heart failure: focus on the obesity paradox

S Carbone, CJ Lavie, R Arena - Mayo Clinic Proceedings, 2017 - Elsevier
The escalating prevalence of obesity has been linked to substantial increases in both
metabolic and cardiovascular disease. Nevertheless, the direct effects of obesity on …

The molecular mechanisms of obesity paradox

AS Antonopoulos, D Tousoulis - Cardiovascular research, 2017 - academic.oup.com
Clinical observations suggest a complex relationship between human obesity and
cardiovascular disease. Whilst abdominal (visceral) adiposity leads to deleterious metabolic …

Body mass index, the most widely used but also widely criticized index: would a criterion standard measure of total body fat be a better predictor of cardiovascular …

FB Ortega, X Sui, CJ Lavie, SN Blair - Mayo Clinic Proceedings, 2016 - Elsevier
Objectives To examine whether an accurate measure (using a criterion standard method) of
total body fat would be a better predictor of cardiovascular disease (CVD) mortality than …

Abdominal obesity is associated with an increased risk of all-cause mortality in patients with HFpEF

T Tsujimoto, H Kajio - Journal of the American College of Cardiology, 2017 - jacc.org
Background: There is a lack of studies that evaluate the association between abdominal
obesity and subsequent outcomes in patients with heart failure with preserved ejection …

From the BMI paradox to the obesity paradox: the obesity–mortality association in coronary heart disease

AS Antonopoulos, EK Oikonomou… - Obesity …, 2016 - Wiley Online Library
Despite a strong association between body weight and mortality in the general population,
clinical evidence suggests better clinical outcome of overweight or obese individuals with …

[HTML][HTML] Obesity and atrial fibrillation: epidemiology, pathophysiology and novel therapeutic opportunities

V Vyas, P Lambiase - Arrhythmia & electrophysiology review, 2019 - ncbi.nlm.nih.gov
Obesity is already a major global public health issue, implicated in a vast array of conditions
affecting multiple body systems. It is now also firmly established as an independent risk …

Body mass index and all‐cause mortality in older adults: a scoping review of observational studies

AA Javed, R Aljied, DJ Allison, LN Anderson… - Obesity …, 2020 - Wiley Online Library
In older age, body composition changes as fat mass increases and redistributes. Therefore,
the current body mass index (BMI) classification may not accurately reflect risk in older …

Decreased skeletal muscle mass is associated with an increased risk of mortality after radical nephrectomy for localized renal cell cancer

SP Psutka, SA Boorjian, MR Moynagh… - The Journal of …, 2016 - auajournals.org
Purpose: We evaluate the association between severe skeletal muscle deficiency or
sarcopenia, and disease progression, cancer specific mortality and all cause mortality in …

Does selection bias explain the obesity paradox among individuals with cardiovascular disease?

HR Banack, JS Kaufman - Annals of epidemiology, 2015 - Elsevier
Objectives The objectives of this article are to demonstrate that the obesity paradox may be
explained by collider stratification bias and to estimate the biasing effects of unmeasured …

The heart failure overweight/obesity survival paradox: the missing sex link

AR Vest, Y Wu, R Hachamovitch, JB Young, L Cho - JACC: Heart Failure, 2015 - jacc.org
Objectives: This study sought to determine whether body mass index (BMI) has a differential
impact on survival for females versus males with advanced systolic heart failure (HF) …