Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
[HTML][HTML] Synthesis and anti-α-glucosidase activity evaluation of betulinic acid derivatives
XZ Wu, WJ Zhu, L Lu, CM Hu, YY Zheng… - Arabian Journal of …, 2023 - Elsevier
In this article, a series of betulinic acid derivatives (3a∼ 3u, 4a∼ 4e) were synthesized
through a stepwise structure optimization and evaluated for their anti-α-glucosidase …
through a stepwise structure optimization and evaluated for their anti-α-glucosidase …
Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives
We have synthesized a series of benzimidazole bearing thiazolidinone derivatives (1-20),
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective
Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry
due to their numerous biological activities. Moreover, many clinical candidates based on this …
due to their numerous biological activities. Moreover, many clinical candidates based on this …
Recent developments in the synthesis of N‐heterocyclic compounds as α‐amylase inhibitors via in‐vitro and in‐silico analysis: Future drugs for treating diabetes
In nature, N‐heterocyclic compounds and their derivatives are abundant. They serve as the
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking …
Abstract Benzotriazoles (4–6) were synthesized which were further reacted with different
substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7 …
substituted benzoic acids and phenacyl bromides to synthesize benzotriazole derivatives (7 …
In vitro α-glucosidase and α-amylase inhibitory potential and molecular docking studies of benzohydrazide based imines and thiazolidine-4-one derivatives
Benzohydrazide based imine derivatives (1c-16c) and thiazolidine-4-one derivatives (1d-
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
Thiadiazole based triazole/hydrazone derivatives: Synthesis, in vitro α-glucosidase inhibitory activity and in silico molecular docking study
Thiadiazole-based hydrazide was treated with different substituted phenyl isothiocyanates
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors
XY Deng, JJ Ke, YY Zheng, DL Li, K Zhang… - Journal of Enzyme …, 2022 - Taylor & Francis
Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised
to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA …
to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA …
Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
Abstract α-Amylase is a target for type-2 diabetes mellitus treatment. However, small
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …
molecule inhibitors of α-amylase are currently scarce. In the course of developing small …