Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2022 - Google Patents
A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …

Spatially encoded biological assays

MS Chee - US Patent 10,982,268, 2021 - Google Patents
Jun. 11, 2019, now Pat. No. 10,494,667, which is a continuation of application No.
16/430,015, filed on Jun. 3, 2019, which is a continuation of application No. 16/414,213, filed …

Spatially encoded biological assays

MS Chee - US Patent 10,996,219, 2021 - Google Patents
The present invention provides assays and assay systems for use in spatially encoded
biological assays. The invention provides an assay system comprising an assay capable of …

Methods and systems for determining spatial patterns of biological targets in a sample

MS Chee, DA Routenberg - US Patent 11,046,996, 2021 - Google Patents
The present disclosure provides methods and assay systems for use in spatially encoded
biological assays, including assays to determine a spatial pattern of abundance, expression …

Methods and systems for determining spatial patterns of biological targets in a sample

MS Chee, DA Routenberg - US Patent 10,927,403, 2021 - Google Patents
The present disclosure provides methods and assay systems for use in spatially encoded
biological assays, including assays to determine a spatial pattern of abundance, expres …

Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2021 - Google Patents
A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …

Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2022 - Google Patents
Extended European Search Report in European Appln. No. 21164322. 6, dated Sep. 6,
2021, 5 pages. Fu et al.,“Repeat subtraction-mediated sequence capture from a complex …

Methods and systems for determining spatial patterns of biological targets in a sample

MS Chee, DA Routenberg - US Patent 11,286,515, 2022 - Google Patents
Oct. 8, 2019, now Pat. No. 10,774,372, which is a continuation of application No.
15/831,158, filed on Dec. 4, 2017, now abandoned, which is a continuation of application …

Methods of detecting analytes

J Frisen, P Stahl, J Lundeberg - US Patent 11,352,659, 2022 - Google Patents
Localized detection of RNA in a tissue sample that includes cells is accomplished on an
array. The array include a number of features on a substrate. Each feature includes a …

Methods and systems for determining spatial patterns of biological targets in a sample

MS Chee, DA Routenberg - US Patent 11,359,228, 2022 - Google Patents
The present disclosure provides methods and assay systems for use in spatially encoded
biological assays, including assays to determine a spatial pattern of abundance, expression …