Neuropathic pain: delving into the oxidative origin and the possible implication of transient receptor potential channels

C Carrasco, M Naziroǧlu, AB Rodríguez… - Frontiers in …, 2018 - frontiersin.org
Currently, neuropathic pain is an underestimated socioeconomic health problem affecting
millions of people worldwide, which incidence may increase in the next years due to …

Naringin and naringenin polyphenols in neurological diseases: understandings from a therapeutic viewpoint

TB Emran, F Islam, N Nath, H Sutradhar, R Das, S Mitra… - Life, 2022 - mdpi.com
The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits,
bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple …

Naringenin reduces inflammatory pain in mice

FA Pinho-Ribeiro, AC Zarpelon, V Fattori… - …, 2016 - Elsevier
Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …

A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production

N Karim, Z Jia, X Zheng, S Cui, W Chen - Trends in Food Science & …, 2018 - Elsevier
Background Metabolic syndromes are the multi-metabolic abnormality characterized by
hyperlipidemia, obesity, hyperglycemia, diabetes, hypertension, cardiovascular disease …

Therapeutic potential of naringin in neurological disorders

S Ahmed, H Khan, M Aschner, MM Hasan… - Food and Chemical …, 2019 - Elsevier
Neurological illnesses are multifactorial incurable debilitating disorders that may cause
neurodegeneration. These diseases influence approximately 30 million people around the …

Naringenin: its chemistry and roles in neuroprotection

AV Atoki, PM Aja, TS Shinkafi, EN Ondari… - Nutritional …, 2024 - Taylor & Francis
According to epidemiological research, as the population ages, neurological illnesses are
becoming a bigger issue. Despite improvements in the treatment of these diseases, there …

Naringenin Inhibits Superoxide Anion-Induced Inflammatory Pain: Role of Oxidative Stress, Cytokines, Nrf-2 and the NO−cGMP−PKG−KATPChannel Signaling …

MF Manchope, C Calixto-Campos, L Coelho-Silva… - PloS one, 2016 - journals.plos.org
In the present study, the effect and mechanism of action of the flavonoid naringenin were
evaluated in superoxide anion donor (KO2)-induced inflammatory pain in mice. Naringenin …

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

FA Pinho-Ribeiro, AC Zarpelon, SS Mizokami… - The Journal of nutritional …, 2016 - Elsevier
Lipopolysaccharide (LPS) is the major structural component of Gram-negative bacteria cell
wall and a highly pro-inflammatory toxin. Naringenin is found in Citrus fruits and exhibits …

Pharmacological properties and therapeutic potential of naringenin: a citrus flavonoid of pharmaceutical promise

N Rani, S Bharti, B Krishnamurthy… - Current …, 2016 - ingentaconnect.com
Naringenin chemically known as 5, 7-dihydroxy-2-(4-hydroxyphenyl) chroman-4-one is a
common dietary polyphenolic constituent of the citrus fruits. It has received considerable …

Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels

P Singh, S Bansal, A Kuhad, A Kumar, K Chopra - Food & function, 2020 - pubs.rsc.org
Diabetes mellitus is a serious debilitating epidemic affecting all social strata, imposing huge
health, social and economic burdens. Diabetic neuropathic pain, an important microvascular …