There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is
intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD …

The dysregulation of energy homeostasis in obesity involves multihormone resistance.
Although leptin and insulin resistance have been well characterized, catecholamine …

White adipose tissue displays high plasticity. We developed a system for the inducible,
permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We …

Mitochondria play a key role in maintaining energy homeostasis in metabolic tissues,
including adipose tissues. The two main types of adipose tissues are the white adipose …

Chronic inflammation constitutes an important link between obesity and its
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …

Obesity develops when energy intake exceeds energy expenditure. Promoting brown
adipose tissue formation and function increases energy expenditure and hence may …

Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

To fulfill its role as the major energy-storing tissue, adipose has several unique properties
that cannot be seen in any other organ, including an almost unlimited capacity to expand in …

Obesity and associated chronic inflammation initiate a state of insulin resistance (IR). The
secretion of chemoattractants such as MCP-1 and MIF and of cytokines IL-6, TNF-α, and IL …