Since its discovery, nerve growth factor (NGF) has long occupied a critical role in
developmental and adult neurobiology for its many important regulatory functions on the …

The physiological role of the neurotrophin nerve growth factor (NGF) has been
characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous …

Optic pathway glioma (OPG), seen in 15% to 20% of individuals with neurofibromatosis type
1 (NF1), account for significant morbidity in young children with NF1. Overwhelmingly a …

Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts
not only outside its classical domain of the peripheral and central nervous system, but also …

Optic pathway gliomas (OPGs) encompass two distinct categories: benign pediatric gliomas,
which are characterized by favorable prognosis, and malignant adult gliomas, which are …

Neurotrophins are a family of proteins that support neuronal proliferation, survival, and
differentiation in the central and peripheral nervous systems, and are regulators of neuronal …

Background Preclinical trials have shown beneficial effects of nerve growth factor (NGF)
administration on visual function in animal models of retinitis pigmentosa (RP). The aim of …

Purpose No approved therapies directly target retinal ganglion cells (RGCs) for
neuroprotection or neuroenhancement in glaucoma. Recombinant human nerve growth …

Paediatric optic pathway gliomas are low-grade brain tumours characterized by slow
progression and invalidating visual loss. Presently there is no strategy to prevent visual loss …

Glioblastoma (GBM) is an aggressive and lethal malignancy of the central nervous system
with a median survival rate of 15 months. We investigated the combined anticancer effects of …