Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) delay progression of metastatic
breast cancer. However, complete responses are uncommon and tumors eventually relapse …

Background During myocardial infarction (MI), the stimulation of the cGAS-STING-IRF3
pathway in infiltrated macrophages can induce the apoptosis of cardiomyocytes and the …

During the last few decades, cell-based anti-tumor immunotherapy emerged and it has
provided us with a large amount of knowledge. Upon chemokines recognition, immune cells …

Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory
properties, but how gene expression programs coordinate this immune cell plasticity is …

Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective
role in the intestine. Although its production by cells of the innate and adaptive immune …

The protozoan parasite Leishmania donovani (L. donovani) causes visceral leishmaniasis, a
chronic infection which is fatal when untreated. Herein, we investigated whether in addition …

DP, MM, ST, and NS designed research; DP, SK, MA, NT, VV, STB, S.-HK, LMJ, J.-JJ, HA,
MM, ST, XP, S.-GO, XZ, and NR performed research; TA and MLT contributed reagents and …

The unresectable or postoperative recurrence of advanced metastatic colorectal cancer
(CRC) is the difficulty of its clinical management, and pharmacological therapy is the main …

Protozoan parasites are known for their remarkable capacity to persist within the bodies of
vertebrate hosts, which frequently results in prolonged infections and the recurrence of …