Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Applications of machine learning in human microbiome studies: a review on feature selection, biomarker identification, disease prediction and treatment

LJ Marcos-Zambrano… - Frontiers in …, 2021 - frontiersin.org
The number of microbiome-related studies has notably increased the availability of data on
human microbiome composition and function. These studies provide the essential material …

Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4

A Blanco-Míguez, F Beghini, F Cumbo, LJ McIver… - Nature …, 2023 - nature.com
Metagenomic assembly enables new organism discovery from microbial communities, but it
can only capture few abundant organisms from most metagenomes. Here we present …

Identification of antimicrobial peptides from the human gut microbiome using deep learning

Y Ma, Z Guo, B Xia, Y Zhang, X Liu, Y Yu, N Tang… - Nature …, 2022 - nature.com
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

M Reyman, MA Van Houten, RL Watson… - Nature …, 2022 - nature.com
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have
pronounced effects on gut microbiome development and selection of antimicrobial …

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

MC Andrews, CPM Duong, V Gopalakrishnan… - Nature medicine, 2021 - nature.com
Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4
and PD-1 is associated with clinical benefit across tumor types, but also a high rate of …

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

EN Baruch, I Youngster, G Ben-Betzalel, R Ortenberg… - Science, 2021 - science.org
The gut microbiome has been shown to influence the response of tumors to anti–PD-1
(programmed cell death–1) immunotherapy in preclinical mouse models and observational …

[HTML][HTML] MicrobiotaProcess: A comprehensive R package for deep mining microbiome

S Xu, L Zhan, W Tang, Q Wang, Z Dai, L Zhou, T Feng… - The Innovation, 2023 - cell.com
The data output from microbiome research is growing at an accelerating rate, yet mining the
data quickly and efficiently remains difficult. There is still a lack of an effective data structure …

[HTML][HTML] Alterations in gut microbiota of patients with COVID-19 during time of hospitalization

T Zuo, F Zhang, GCY Lui, YK Yeoh, AYL Li, H Zhan… - Gastroenterology, 2020 - Elsevier
Background & Aims Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infects gastrointestinal tissues, little is known about the roles of gut commensal microbes …

Using MicrobiomeAnalyst for comprehensive statistical, functional, and meta-analysis of microbiome data

J Chong, P Liu, G Zhou, J Xia - Nature protocols, 2020 - nature.com
MicrobiomeAnalyst is an easy-to-use, web-based platform for comprehensive analysis of
common data outputs generated from current microbiome studies. It enables researchers …