The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer's disease

A Verma, DK Waiker, B Bhardwaj, P Saraf… - Bioorganic …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurological illness that causes dementia mainly
in the elderly. The challenging obstacles related to AD has freaked global healthcare system …

Quinazolines: new horizons in anticonvulsant therapy

VG Ugale, SB Bari - European journal of medicinal chemistry, 2014 - Elsevier
The search for novel anticonvulsants with more selectivity and lower toxicity continues to be
an area of intensive investigation in medicinal chemistry. The potency and selectivity in the …

Catalyst-free synthesis of imidazo [5, 1-b] quinazolines and their antimicrobial activity

PJ Patel, RM Vala, SG Patel, DB Upadhyay… - Journal of Molecular …, 2023 - Elsevier
Abstract In this study, imidazo [5, 1-b] quinazoline derivatives 4 (a–t) were synthesized via a
three-component reaction of 5-aminoimidazole-4-carbonitrile, 1, 3-cyclohexanedione …

Utilization of isatoic anhydride in the syntheses of various types of quinazoline and quinazolinone derivatives

SY Abbas, KAM El-Bayouki… - Synthetic …, 2016 - Taylor & Francis
Isatoic anhydride has attracted a great deal of attention in recent decades. A review of the
methods of preparation of all known quinazoline and quinazolinone derivatives is given …

Simple circular dichroism method for selection of the optimal cyclodextrin for drug complexation

E Kiss, VA Szabó, P Horváth - Journal of Inclusion Phenomena and …, 2019 - Springer
Cyclodextrins are very important excipients in the pharmaceutical industry. Given the
multitude of native and semisynthetic cyclodextrin derivatives, there is a need for a rapid and …

1, 2, 3-Triazole–quinazolin-4 (3 H)-one conjugates: evolution of ergosterol inhibitor as anticandidal agent

MM Masood, M Irfan, P Khan, MF Alajmi, A Hussain… - RSC …, 2018 - pubs.rsc.org
The present study describes the synthesis of 1, 2, 3-triazole–quinazolinone conjugates (5a–
q) from ethyl 4-oxo-3-(prop-2-ynyl)-3, 4-dihydroquinazoline-2-carboxylate and phenyl …

Position-selective synthesis and biological evaluation of four isomeric A-ring amino derivatives of the alkaloid luotonin A

A Ibric, S Eckerstorfer, M Eder, I Louko, L Tunjic… - Molecules, 2019 - mdpi.com
Following two orthogonal synthetic routes, a series of all four possible A-ring amino
derivatives of the natural product Luotonin A (a known Topoisomerase I inhibitor) was …

Isatoic anhydride: a fascinating and basic molecule for the synthesis of substituted quinazolinones and benzo di/triazepines

Z Tashrifi… - Current Organic …, 2019 - ingentaconnect.com
This review article is focused on the synthesis of compounds with quinazolinones and benzo
di/triazepine scaffolds. These invaluable derivatives are of great interest in medicinal and …

Synthesis and Chemistry of Benzo[e][1,2,6]thiadiazino[3,4-b][1,4]diazepin-10(11H)-ones and Related Ring Transformations

AS Kalogirou, A Kourtellaris… - The Journal of Organic …, 2021 - ACS Publications
2-[(3, 5-Dichloro-4 H-1, 2, 6-thiadiazin-4-ylidene) amino] benzamides are cyclized to benzo
[e][1, 2, 6] thiadiazino [3, 4-b][1, 4] diazepin-10 (11 H)-ones via (i) treatment with NaH and via …

A convenient one-pot synthesis of novel benzo [g] benzo [4, 5] imidazo [2, 1-b] quinazolines through Knoevenagel/Michael/Cyclization cascade reaction

M Ahmadusefi-Sarhadi, H Mehrabi, F Alizadeh-Bami… - Tetrahedron …, 2024 - Elsevier
A cost‐effective protocol has been used for the synthesis of novel benzo [g] benzo [4, 5]
imidazo [2, 1-b] quinazoline derivatives. This domino, one‐pot, three‐component reaction …