The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the
deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which …

Introduction Erectile dysfunction (ED) is an important health concern that can significantly
affect a man's psychosocial well-being. ED has traditionally been considered a disease of …

Compelling evidence exists for pervasive sex differences in pathological conditions,
including anxiety and depressive disorders, with females more than twice as likely to be …

The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the
regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for …

Estradiol and testosterone are powerful steroid hormones that impact brain function in
numerous ways. During development, these hormones can act to program the adult brain in …

Considerable research has shown that testosterone regulates many physiological systems,
modulates clinical disorders, and contributes to health outcome. However, studies on the …

There are a significant number of men under 40 who experience erectile dysfunction (ED). In
the past, the vast majority of cases were thought to be psychogenic in nature. Studies have …

According to World Health Organization estimates, 5% of the adult population worldwide
suffers from depression. In addition to the affective, psychomotor and cognitive symptoms …

BACKGROUND: In the last decade, there has been a surge of new clinical trials studying the
impact of exogenous testosterone on mood. The results of these studies have been …