The low-density lipoprotein (LDL) receptor family consists of several related scavenger
receptors that not only function as important cargo transporters, but also inform the cell of …

Heymann nephritis (HN) has been extensively studied as a model of human membranous
nephropathy since it was first described by Heymann in 1959. HN was induced in active …

We completed the cDNA cloning and sequencing of gp330, the major kidney glomerular
antigen for rat Heymann nephritis. The deduced 4660-aa sequence, expected to constitute a …

Telomere-dependent replicative senescence is one of the mechanisms that limit the number
of population doublings of normal human cells. By overexpression of telomerase, cells of …

Glycoprotein 330 (gp330) is an endocytic receptor expressed in the renal proximal tubules
and some other absorptive epithelia, eg, in the inner ear. The present study shows that the …

Low-density lipoprotein receptor-related protein (LRP) mediates internalization of urokinase:
plasminogen activator inhibitor complexes (uPA: PAI-1) and the urokinase receptor (uPAR) …

Megalin, a member of the low density lipoprotein receptor gene family, is required for
efficient protein absorption in the proximal tubule. Recent studies have shown that the low …

We have sought to identify a high-capacity transport system that mediates transcytosis of
proteins from the blood to the brain. The 39 kDa receptor-associated protein (RAP) functions …

We present here the complete primary structure of human gp330, the human variant of the
principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats. The …

The renal proximal tubule exhibits a very extensive apical endocytic apparatus consisting of
an elaborate network of coated pits and small coated and noncoated endosomes. In …