Myocardial mesostructure and mesofunction

AJ Wilson, GB Sands, IJ LeGrice… - American Journal of …, 2022 - journals.physiology.org
The complex and highly organized structural arrangement of some five billion
cardiomyocytes directs the coordinated electrical activity and mechanical contraction of the …

Emerging techniques in cardiac magnetic resonance imaging

R Guo, S Weingärtner, P Šiurytė… - Journal of Magnetic …, 2022 - Wiley Online Library
Cardiovascular disease is the leading cause of death and a significant contributor of health
care costs. Noninvasive imaging plays an essential role in the management of patients with …

Using synthetic data generation to train a cardiac motion tag tracking neural network

M Loecher, LE Perotti, DB Ennis - Medical image analysis, 2021 - Elsevier
A CNN based method for cardiac MRI tag tracking was developed and validated. A synthetic
data simulator was created to generate large amounts of training data using natural images …

How drugs modulate the performance of the human heart

M Peirlinck, J Yao, F Sahli Costabal, E Kuhl - Computational Mechanics, 2022 - Springer
Many drugs interact with ion channels in the cells of our heart and trigger heart rhythm
disorders with potentially fatal consequences. Computational modeling can provide …

Anatomically-guided deep learning for left ventricle geometry generation with uncertainty quantification based on short-axis MR images

A Von Zuben, LE Perotti, FAC Viana - Engineering Applications of Artificial …, 2023 - Elsevier
Recent advances in deep learning have greatly improved the ability to generate analysis
models from medical images. In particular, great attention is focused on quickly generating …

A simple and efficient adaptive time stepping technique for l ow‐order operator splitting schemes applied to cardiac electrophysiology

D Ogiermann, LE Perotti… - International Journal for …, 2023 - Wiley Online Library
We present a simple, yet efficient adaptive time stepping scheme for cardiac
electrophysiology (EP) simulations based on standard operator splitting techniques. The …

[HTML][HTML] An explicit local space-time adaptive framework for monodomain models in cardiac electrophysiology

D Ogiermann, D Balzani, LE Perotti - Computer Methods in Applied …, 2024 - Elsevier
We present a new explicit local space–time adaptive framework to decrease the time
required for monodomain simulations for cardiac electrophysiology. Based on the localized …

An extended generalized Hill model for cardiac tissue: Comparison with different approaches based on experimental data

D Ogiermann, D Balzani, LE Perotti - … imaging and modeling of the heart, 2023 - Springer
In this work we discuss advantages and drawbacks of active mechanics frameworks often
used to represent the material response of cardiac tissue. A formal analysis of the models is …

Arbitrary point tracking with machine learning to measure cardiac strains in tagged MRI

M Loecher, AJ Hannum, LE Perotti… - … Conference on Functional …, 2021 - Springer
Cardiac tagged MR images allow for deformation fields to be measured in the heart by
tracking the motion of tag lines throughout the cardiac cycle. Machine learning (ML) …

Native-resolution myocardial principal Eulerian strain mapping using convolutional neural networks and Tagged Magnetic Resonance Imaging

IA Yassine, AM Ghanem, NS Metwalli, A Hamimi… - Computers in biology …, 2022 - Elsevier
Background Assessment of regional myocardial function at native pixel-level resolution can
play a crucial role in recognizing the early signs of the decline in regional myocardial …