DNA damage kinase signaling: checkpoint and repair at 30 years
From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
Hydroxyurea—the good, the bad and the ugly
MW Musiałek, D Rybaczek - Genes, 2021 - mdpi.com
Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …
DNA repair pathways as targets for cancer therapy
T Helleday, E Petermann, C Lundin, B Hodgson… - Nature Reviews …, 2008 - nature.com
DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function. To date …
proteomics to decipher the encoded protein networks that dictate cellular function. To date …
Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways
GK Azad, RS Tomar - Molecular biology reports, 2014 - Springer
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …
multifunctional compound, which catalyzes several essential reactions for the protection of …
Sensing and repairing DNA double-strand breaks
SP Jackson - Carcinogenesis, 2002 - academic.oup.com
The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
Ribonucleotide reductases
P Nordlund, P Reichard - Annu. Rev. Biochem., 2006 - annualreviews.org
Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …
Checkpoint responses to DNA double-strand breaks
DP Waterman, JE Haber… - Annual review of …, 2020 - annualreviews.org
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …
A comprehensive analysis of replicative lifespan in 4,698 single-gene deletion strains uncovers conserved mechanisms of aging
MA McCormick, JR Delaney, M Tsuchiya… - Cell metabolism, 2015 - cell.com
Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …
An overview of Cdk1-controlled targets and processes
JM Enserink, RD Kolodner - Cell division, 2010 - Springer
The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …
model organism S. cerevisiae. Research performed during the past decade has significantly …