Patient-derived xenograft (PDX) models are created by engraftment of patient tumor tissues
into immunocompetent mice. Since a PDX model retains the characteristics of the primary …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Profiling candidate therapeutics with limited cancer models during preclinical development
hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous …

Targeted therapies and immunotherapies have transformed melanoma care, extending
median survival from∼ 9 to over 25 months, but nevertheless most patients still die of their …

Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-
infiltrating T cells have shown durable responses in patients with melanoma. To study ACT …

The principles that govern the evolution of tumors exposed to targeted therapy are poorly
understood. Here we modeled the selection and propagation of an amplification in the BRAF …

Acral lentiginous melanoma is a histological subtype of cutaneous melanoma that occurs in
the glabrous skin of the palms, soles and the nail unit. Although in some countries …

Background Mouse xenografts from (patient-derived) tumors (PDX) or tumor cell lines are
widely used as models to study various biological and preclinical aspects of cancer …

Therapy of advanced melanoma is changing dramatically. Following mutational and
biological subclassification of this heterogeneous cancer, several targeted and immune …

Different MTH1 inhibitors have different ability to kill cancer cells. Here we demonstrate that
the lack of efficiency of some MTH1 inhibitors is explained by their inability introduce the …