Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all
humans. Hcy is degraded in the body through two metabolic pathways, while a minor part is …

Background Cardiovascular disease, which includes coronary artery disease, stroke and
peripheral vascular disease, is a leading cause of death worldwide. Homocysteine is an …

This text is intended for those who wish to understand the complex relationships between
diet and risks of important diseases, such as cancer and cardiovascular disease. It is aimed …

Objective: To assess whether the association of serum homocysteine concentration with
ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is …

Background and Purpose—This guideline provides an overview of the evidence on various
established and potential stroke risk factors and provides recommendations for the reduction …

Background In observational studies, lower homocysteine levels are associated with lower
rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower …

ContextIn observational studies, elevated plasma total homocysteine levels have been
positively associated with ischemic stroke risk. However the utility of homocysteine-lowering …

Rationale: Endothelial injury is an initial mechanism mediating cardiovascular disease.
Objective: Here, we investigated the effect of hyperhomocysteinemia on programed cell …

Astrocyte reactivity is a hallmark of neuroinflammation that arises with Alzheimer's disease
(AD) and nearly every other neurodegenerative condition. While astrocytes certainly …

The endoplasmic reticulum (ER) is a multifunctional organelle within which protein folding,
lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient …