[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

[HTML][HTML] lifex: A flexible, high performance library for the numerical solution of complex finite element problems

PC Africa - SoftwareX, 2022 - Elsevier
Numerical simulations are ubiquitous in mathematics and computational science. Several
industrial and clinical applications entail modeling complex multiphysics systems that evolve …

[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

F Regazzoni, M Salvador, PC Africa, M Fedele… - Journal of …, 2022 - Elsevier
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

[HTML][HTML] Beyond CFD: Emerging methodologies for predictive simulation in cardiovascular health and disease

EL Schwarz, L Pegolotti, MR Pfaller… - Biophysics Reviews, 2023 - pubs.aip.org
Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

PC Africa, I Fumagalli, M Bucelli, A Zingaro… - Computer Physics …, 2024 - Elsevier
Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

lifex-fiber: an open tool for myofibers generation in cardiac computational models

PC Africa, R Piersanti, M Fedele, L Dede'… - BMC …, 2023 - Springer
Background Modeling the whole cardiac function involves the solution of several complex
multi-physics and multi-scale models that are highly computationally demanding, which call …

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

PC Africa, R Piersanti, F Regazzoni, M Bucelli… - BMC …, 2023 - Springer
Background Simulating the cardiac function requires the numerical solution of multi-physics
and multi-scale mathematical models. This underscores the need for streamlined, accurate …

Advancement in computational simulation and validation of congenital heart disease: A review

AFA Ahmad Azahari, WN Wan Ab Naim… - Computer Methods in …, 2024 - Taylor & Francis
The improvement in congenital heart disease (CHD) treatment and management has
increased the life expectancy in infants. However, the long-term efficacy is difficult to assess …